解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and c...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.11.002
更新日期:2013-12-09 00:00:00
abstract::Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global reduction of the r...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.10.006
更新日期:2013-11-11 00:00:00
abstract::A large body of evidence indicates that chronic inflammation is one of several key risk factors for cancer initiation, progression, and metastasis. However, the underlying mechanisms responsible for the contribution of inflammation and inflammatory mediators to cancer remain elusive. Here, we present genetic evidence ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.10.009
更新日期:2013-11-11 00:00:00
abstract::EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers with wild-type EGFR...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.09.004
更新日期:2013-10-14 00:00:00
abstract::Monosomy 7 and interstitial deletion of 7q (-7/7q-) are well-recognized nonrandom chromosomal abnormalities frequently found among patients with myelodysplastic syndromes (MDSs) and myeloid leukemias. We previously identified candidate myeloid tumor suppressor genes (SAMD9, SAMD9-like = SAMD9L, and Miki) in the 7q21.3...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.08.011
更新日期:2013-09-09 00:00:00
abstract::Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.06.017
更新日期:2013-08-12 00:00:00
abstract::Androgen deprivation therapy (ADT) for advanced prostate cancer inexorably leads to resistance, and clinically useful biomarkers are lacking. The value of genetically engineered mice for coclinical studies is clearly demonstrated in a recent publication that reveals XAF1, XIAP, and SRD5A1 as novel predictive biomarker...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.06.007
更新日期:2013-07-08 00:00:00
abstract::Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show that methotrexate (MTX) induces microphthalmia-associated transcription fac...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.05.009
更新日期:2013-07-08 00:00:00
abstract::Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.04.026
更新日期:2013-06-10 00:00:00
abstract::ERK pathway activation in cells expressing wild-type BRAF is a well-reported, clinically-relevant adverse effect of the otherwise impressive response of BRAF(V600E)-mutated melanomas to RAF inhibitors. In this issue of Cancer Cell, Holderfield and colleagues show that RAF autoinhibition underpins this paradox, further...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2013.04.021
更新日期:2013-05-13 00:00:00
abstract::The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent ch...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.04.011
更新日期:2013-05-13 00:00:00
abstract::Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2013.04.004
更新日期:2013-04-15 00:00:00
abstract::Cancer cells reprogram their metabolism using different strategies to meet energy and anabolic demands to maintain growth and survival. Understanding the molecular and genetic determinants of these metabolic programs is critical to successfully exploit them for therapy. Here, we report that the oncogenic melanocyte li...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.11.020
更新日期:2013-03-18 00:00:00
abstract::Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitoc...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.02.003
更新日期:2013-03-18 00:00:00
abstract::The molecular mechanisms regulating leukemia-initiating cell (LIC) function are of important clinical significance. We use chronic myelogenous leukemia (CML) as a model of LIC-dependent malignancy and identify the interaction between the ubiquitin ligase Fbw7 and its substrate c-Myc as a regulator of LIC homeostasis. ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.01.025
更新日期:2013-03-18 00:00:00
abstract::Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and create...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2013.01.017
更新日期:2013-02-11 00:00:00
abstract::Loss of p53 is considered to allow progression of colorectal tumors from the adenoma to the carcinoma stage. Using mice with an intestinal epithelial cell (IEC)-specific p53 deletion, we demonstrate that loss of p53 alone is insufficient to initiate intestinal tumorigenesis but markedly enhances carcinogen-induced tum...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.11.014
更新日期:2013-01-14 00:00:00
abstract::Using sequential gene expression profiling (GEP) samples, we defined a major functional group related to drug resistance that contains chromosomal instability (CIN) genes. One CIN gene in particular, NEK2, was highly correlated with drug resistance, rapid relapse, and poor outcome in multiple cancers. Overexpressing N...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.12.001
更新日期:2013-01-14 00:00:00
abstract::Adaptive resistance to PI3K-mTOR inhibitors potentially limits the clinical antitumor activities of these agents. In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion....
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.11.012
更新日期:2012-12-11 00:00:00
abstract::In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved t...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.10.008
更新日期:2012-11-13 00:00:00
abstract::To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis ident...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.10.007
更新日期:2012-11-13 00:00:00
abstract::In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for th...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.10.001
更新日期:2012-10-16 00:00:00
abstract::We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 t...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.09.003
更新日期:2012-10-16 00:00:00
abstract::Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for react...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.08.020
更新日期:2012-09-11 00:00:00
abstract::Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of grow...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.08.004
更新日期:2012-09-11 00:00:00
abstract::Homeobox domain-containing transcription factors are important regulators of hematopoiesis. Here, we report that increased levels of nonclustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and blocked differenti...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.06.027
更新日期:2012-08-14 00:00:00
abstract::The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but not normal tissues. Treatment of tumor-bear...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.05.014
更新日期:2012-07-10 00:00:00
abstract::The tumor suppressor cylindromatosis (CYLD) inhibits the NFκB and mitogen-activated protein kinase (MAPK) activation pathways by deubiquitinating upstream regulatory factors. Here we show that liver-specific disruption of CYLD triggers hepatocyte cell death in the periportal area via spontaneous and chronic activation...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.04.026
更新日期:2012-06-12 00:00:00
abstract::In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmacological inhibition of GATA2-mediated pathways with bortezomib and fasudil results in dramatic tumor inhibition. These observations...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.04.032
更新日期:2012-05-15 00:00:00
abstract::Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of c...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.01.021
更新日期:2012-04-17 00:00:00
abstract::Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing differentiation and a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.03.014
更新日期:2012-04-17 00:00:00
abstract::Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration o...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.03.001
更新日期:2012-03-20 00:00:00
abstract::Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of the disease. Here, we show that cerebellar stem cells expressi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.12.021
更新日期:2012-02-14 00:00:00
abstract::Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, transiently normalize abnormal tumor vasculature and contribute to improved delivery of subsequent chemotherapy. To investigate this concept, ...
journal_title:Cancer cell
pub_type: 临床试验,杂志文章
doi:10.1016/j.ccr.2011.11.023
更新日期:2012-01-17 00:00:00
abstract::We show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a RAS-dependent manner. Critically, because RAS is activated by BCR-ABL, in drug-resistant chronic myeloid leukemia (CML) cells, RAS activity persists in the pre...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.11.004
更新日期:2011-12-13 00:00:00
abstract::Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating β-catenin le...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.10.030
更新日期:2011-12-13 00:00:00
abstract::Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sens...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2011.10.026
更新日期:2011-11-15 00:00:00
abstract::To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.10.015
更新日期:2011-11-15 00:00:00
abstract::Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a increases the level and nuclear tran...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.08.016
更新日期:2011-10-18 00:00:00
abstract::Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.08.019
更新日期:2011-09-13 00:00:00